During emergencies, MCVS is the state agency responsible for coordinating volunteer efforts and donations management. Designated by the Mississippi Emergency Management Agency (MEMA) to coordinate volunteer assistance to communities affected by disasters, MCVS can activate Volunteer Response Centers (VRCs), serving multiple functions for local communities and for the individuals and organizations mediating disaster aftermath.

Volunteer Response Centers act as registration and deployment points for volunteers, coordinating requests for assistance from affected residents with the skills and resources of voluntary groups. MCVS works closely with the MS chapter of Voluntary Organizations Active in Disaster (MSVOAD), MEMA, national disaster response organizations, and local groups and citizens to coordinate available resources on the group, matching skills and capacities with the people who need them most. 

When disaster strikes Mississippi, volunteers will be able to pre-register with MCVS to receive up-to-date information about when it is safe to respond, and where and when volunteers are most needed. Volunteers should never self-deploy to a disaster-stricken area, and MCVS encourages those who want to prepare to volunteer after a disaster to seek training from a recognized VOAD member organization in advance.